Ac2-26
Product Specifications
UNSPSC Description
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue[1].
Target Antigen
Annexin A; NF-κB
Type
Peptides
Related Pathways
Cytoskeleton;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac2-26.html
Purity
99.14
Solubility
DMSO : 20 mg/mL (ultrasonic;adjust pH to 2 with HCl)|H2O : 7.14 mg/mL (adjust pH to 10 with NaOH)|H2O : 8.33 mg/mL (adjust pH to 8 with 0.1 N NaOH)
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](C)NC(C)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight
3089.43
References & Citations
[1]Liao WI, et al. Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury. Int J Mol Sci. 2017 Aug 15;18(8). pii: E1771.Cancer Cell. 2023 May 8;41(5):903-918.e8.|Signal Transduct Target Ther. 2024 Aug 23;9(1):218.|iScience. 2023 Oct 3.|World J Gastroenterol. 2023 Jun 14, 29(22): 3422-3439.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1098/Ac2-26-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1098/Ac2-26-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
151988-33-9
Available Sizes
Curated Selection
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