Sodium benzoate

Sodium benzoate is an orally active pharmaceutical excipient, such as an antibacterial agent, preservative, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.Sodium benzoate activates NF-κB and induces Apoptosis. Sodium benzoate induces immune suppression and produces reproductively toxic. Sodium benzoate can be used for colon cancer and immune disease research[1][2][3][4][5].

Product Specifications

CAS Number

[532-32-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Biochemical Assay Reagents; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB; Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sodium-benzoate.html

Purity

99.75

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 100 mg/mL

Smiles

O=C(O[Na])C1=CC=CC=C1

Molecular Formula

C7H5NaO2

Molecular Weight

144.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.|[2]Olofinnade AT, et al. The potential toxicity of food-added sodium benzoate in mice is concentration-dependent. Toxicol Res (Camb) . 2021 May 17;10 (3) :561-569. |[3]El-Shennawy L, et al. Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis. Reprod Toxicol. 2020 Dec;98:92-98. |[4]Arabsolghar R, et al. The protective effect of sodium benzoate on aluminum toxicity in PC12 cell line. Res Pharm Sci. 2017 Oct;12 (5) :391-400. |[5]Yadav A, et al. Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic dose. Food Chem Toxicol. 2016 Feb;88:40-7. |[6]Yilmaz B, et al. Food Additive Sodium Benzoate (NaB) Activates NFκB and Induces Apoptosis in HCT116 Cells. Molecules. 2018 Mar 22;23 (4) :723.