Danofloxacin (mesylate)

Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2) [1][2][3].

Product Specifications

CAS Number

[119478-55-6]

Product Name Alternative

CP 76136-27

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; P-glycoprotein

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Danofloxacin-mesylate.html

Purity

99.88

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O.CS(=O)(O)=O

Molecular Formula

C20H24FN3O6S

Molecular Weight

453.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Giles, C.J., et al., Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J Vet Pharmacol Ther, 1991. 14 (4) : p. 400-10.|[2]Schrickx JA, et al. Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters. Br J Pharmacol. 2007 Feb;150 (4) :463-9.|[3]Sartini I, et al. Danofloxacin pharmacokinetics and tissue residues in Bilgorajska geese. Res Vet Sci. 2021 May;136:11-17.