NVP-QAV680

NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with low nanomolar (nM) functional potency to inhibit CRTh2-driven activation of human eosinophils and Th2 lymphocytes. NVP-QAV680 exhibits good oral bioavailability and demonstrates efficacy in CRTh2-dependent mechanisms and allergic disease models in rats[1][2].

Product Specifications

CAS Number

[872365-16-7]

UNSPSC

12352005

Target

CRTH2 (GPR44) ; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nvp-qav680.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CC1=C(C)N(CC2=CC=C(S(=O)(C)=O)C=C2)C3=NC=CC=C31

Molecular Formula

C18H18N2O4S

Molecular Weight

358.41

References & Citations

[1]Sandham DA, et al. Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21 (21) :6582-91.|[2]Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases