HhAntag
HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway[1].
Product Specifications
CAS Number
[496794-70-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HhAntag.html
Purity
99.40
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=CC=C(Cl)C(C2=NC3=CC=C(N(C)C)C=C3N2)=C1)C4=CC(OC)=CC(OC)=C4
Molecular Formula
C24H23ClN4O3
Molecular Weight
450.92
Precautions
H315, H319, H335
References & Citations
[1]Neeraj Mahindroo, et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorg Med Chem. 2010 Jul 1;18 (13) :4801-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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