DN401

DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM) . DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities[1].

Product Specifications

CAS Number

[2135749-60-7]

Product Name Alternative

Panvotinib-401; Pan-401

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dn401.html

Purity

99.0

Solubility

DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC(Cl)=C2C(N(N=C2)CC3=C(C=C4OCOC4=C3)Br)=N1

Molecular Formula

C13H9BrClN5O2

Molecular Weight

382.60

References & Citations

[1]Hye-Kyung Park, et al. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J Med Chem. 2017 Sep 14;60 (17) :7569-7578.