Tin protoporphyrin IX dichloride

Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

Product Specifications

CAS Number

[14325-05-4]

Product Name Alternative

Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tin-protoporphyrin-ix-dichloride.html

Purity

96.2

Solubility

0.1 M NaOH : 12.5 mg/mL (ultrasonic) |1M NaOH : 5 mg/mL (ultrasonic) |DMSO : 0.5 mg/mL (ultrasonic; warming)

Smiles

[Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5)[Cl-]

Molecular Formula

C34H32Cl2N4O4Sn

Molecular Weight

750.26

Precautions

H315, H319, H335

References & Citations

[1]Abdalla MY, et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.