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Tin protoporphyrin IX dichloride

Product Specifications

UNSPSC Description

Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

Target Antigen

Reactive Oxygen Species

Type

Reference compound

Related Pathways

Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tin-protoporphyrin-ix-dichloride.html

Purity

96.0

Solubility

0.1 M NaOH : 12.5 mg/mL (ultrasonic)|1M NaOH : 5 mg/mL (ultrasonic)|DMF : 1 mg/mL (ultrasonic;warming)|DMSO : 0.5 mg/mL (ultrasonic;warming)

Smiles

[Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5)[Cl-]

Molecular Weight

750.26

References & Citations

[1]Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101194/Tin-protoporphyrin-IX-dichloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101194/Tin-protoporphyrin-IX-dichloride-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

14325-05-4

Available Sizes

Curated Selection

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