Triglycidyl isocyanurate

Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].

Product Specifications

CAS Number

[2451-62-9]

Product Name Alternative

TGIC

UNSPSC

12352005

Hazard Statement

H301+H331, H317, H318, H340, H412

Target

Apoptosis; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/triglycidyl-isocyanurate.html

Purity

99.56

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N(C1=O)CC2CO2)N(C(N1CC3CO3)=O)CC4CO4

Molecular Formula

C12H15N3O6

Molecular Weight

297.26

Precautions

H301+H331, H317, H318, H340, H412

References & Citations

[1]Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143|[2]Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008