Cuminaldehyde

Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM) . Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[122-03-2]

Product Name Alternative

P-Isopropylbenzaldehyde

UNSPSC

12352005

Hazard Statement

H227, H302

Target

α-synuclein

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cuminaldehyde.html

Purity

99.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=CC1=CC=C(C(C)C)C=C1

Molecular Formula

C10H12O

Molecular Weight

148.21

Precautions

H227, H302

References & Citations

[1]Morshedi D, et al. Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity. J Food Sci. 2015 Oct;80 (10) :H2336-45.|[2]Tsai, et al. "Cuminaldehyde from Cinnamomum verum induces cell death through targeting topoisomerase 1 and 2 in human colorectal adenocarcinoma COLO 205 cells." Nutrients 8.6 (2016) : 318.|[3]Tomy, et al. "Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation." Applied biochemistry and biotechnology 174 (2014) : 388-397.|[4]Wongkattiya, et al. "Antibacterial activity of cuminaldehyde on food-borne pathogens, the bioactive component of essential oil from Cuminum cyminum L. collected in Thailand." Journal of Complementary and Integrative Medicine 16.4 (2019) .|[5]Dan Xu, et al. "Cuminaldehyde in cumin essential oils prevents the growth and aflatoxin B1 biosynthesis of Aspergillus flavus in peanuts." Food Control 125 (2021) : 107985.|[6]Koohsari, et al. "Antinociceptive and antineuropathic effects of cuminaldehyde, the major constituent of Cuminum cyminum seeds: Possible mechanisms of action." Journal of ethnopharmacology 255 (2020) : 112786.|[7]Hoi-Seon Lee, et al. "Cuminaldehyde: aldose reductase and α-glucosidase inhibitor derived from Cuminum cyminum L. seeds." Journal of agricultural and food chemistry 53.7 (2005) : 2446-2450.