Florfenicol

Florfenicol ((-) -Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions[6][7].

Product Specifications

CAS Number

[73231-34-2]

Product Name Alternative

(-) -Florfenicol; SCH-25298

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Florfenicol.html

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](CF)[C@H](O)C1=CC=C(S(=O)(C)=O)C=C1)C(Cl)Cl

Molecular Formula

C12H14Cl2FNO4S

Molecular Weight

358.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Hu D, et al. Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts. Sci Rep. 2017 Oct 19;7 (1) :13554.|[2]Arslan P, et al. In vitro effects of erythromycin and florfenicol on primary cell lines of Unio crassus and Cyprinus carpio. Environ Sci Pollut Res Int. 2021 Sep;28 (35) :48408-48416.|[3]Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11:213. |[4]Wang X, et al. Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway. Poult Sci. 2022 Nov;101 (11) :102152.|[5]Lis M, et al. Modulation of lymphocyte subsets and humoral immune response by florfenicol administered to sheep red blood cell-immunized broiler chickens. Pol J Vet Sci. 2019 Dec;22 (4) :481-487. |[6]Xinxin C, et al. Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3. Clin Immunol. 2011 Feb;138 (2) :231-8. |[7]Shuang G, et al. Immunosuppressive activity of florfenicol on the immune responses in mice. Immunol Invest. 2011;40 (4) :356-66.