UCB-9260
Product Specifications
UNSPSC Description
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer.?UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar?Kd?of 13?nM[1].
Target Antigen
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/ucb-9260.html
Smiles
OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C
Molecular Weight
423.51
References & Citations
[1]O'Connell J, et al.Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.Nat Commun. 2019 Dec 19;10(1):5795.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133122/UCB-9260-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133122/UCB-9260-SDS-MedChemExpress.pdf
CAS Number
1515888-53-5
Available Sizes
Curated Selection
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