UCB-9260
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1].
Product Specifications
CAS Number
[1515888-53-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/ucb-9260.html
Purity
98.38
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C
Molecular Formula
C26H25N5O
Molecular Weight
423.51
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133122/UCB-9260-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133122/UCB-9260-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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