UCB-9260

UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1].

Product Specifications

CAS Number

[1515888-53-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/ucb-9260.html

Purity

98.38

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C

Molecular Formula

C26H25N5O

Molecular Weight

423.51

Precautions

H302, H315, H319

References & Citations

[1]O'Connell J, et al.Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.Nat Commun. 2019 Dec 19;10 (1) :5795.