FLT3D835Y/F691L-IN-1
Selected Variant
HY-158265
Size: 1 Each
FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor of FLT3 3-tyrosine kinase domain D835Y/F691L secondary mutations with IC50s of 1.5 and 9.7 nM. FLT3D835Y/F691L-IN-1 can be used for acute myeloid leukemia research[1].
Product Specifications
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3d835y-f691l-in-1.html
Solubility
10 mM in DMSO
Smiles
CCC1=C2N=C(NC3=CC(OCCOCCN(CC4)CCC4N2)=C(C=C3)N5CCOCC5)C(C(N)=O)=N1
Molecular Formula
C26H37N7O4
Molecular Weight
511.62
References & Citations
[1]Zheng X, et al. Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations. ACS Pharmacol Transl Sci. 2024 Apr 11;7 (5) :1485-1506.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
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