21-Desacetyldeflazacort

21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609) . Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration[1].

Product Specifications

CAS Number

[13649-57-5]

Product Name Alternative

21-desDFZ

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/21-desacetyldeflazacort.html

Purity

99.23

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(CC4)=CC(C=C5)=O)C)([H])[C@H](C3)O)([H])C[C@@]1([H])OC(C)=N2)C)=O

Molecular Formula

C23H29NO5

Molecular Weight

399.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Möllmann H, et al. Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharm Res. 1995 Jul;12 (7) :1096-100.