MC-DOXHZN (hydrochloride)

MC-DOXHZN ((E/Z) -Aldoxorubicin) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties[1].

Product Specifications

CAS Number

[480998-12-7]

Product Name Alternative

(E/Z) -Aldoxorubicin (hydrochloride) ; Doxorubicin (6-maleimidocaproyl) hydrazone (hydrochloride)

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MC-DOXHZN_hydrochloride.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1.[H]Cl

Molecular Formula

C37H43ClN4O13

Molecular Weight

787.21

References & Citations

[1]Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug Delivery Journal, 2008, 2, 77-85.|[2]Inoh K, et al. Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug[J]. Japanese journal of clinical oncology, 2006, 36 (4) : 207-211.