Graphislactone A

Graphislactone A is an antioxidant, which is found in Cephalosporium IFB-E001 and M. olivacea. Graphislactone A inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM. Graphislactone A is promising for research of oxidative damage-initiated diseases[1][2].

Product Specifications

CAS Number

52179-44-9

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/graphislactone-a.html

Smiles

O=C1OC2=C(C(OC)=CC(C)=C2C3=CC(OC)=CC(O)=C13)O

Molecular Formula

C16H14O6

Molecular Weight

302.28

References & Citations

[1]Song YC, et al. Characterization of graphislactone A as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides. Biol Pharm Bull. 2005 Mar;28 (3) :506-9. |[2]Hormazabal E, et al. Metabolites from Microsphaeropsis olivacea, an endophytic fungus of Pilgerodendron uviferum. Z Naturforsch C J Biosci. 2005 Jan-Feb;60 (1-2) :11-21.