5-Hydroxydecanoate (sodium)

5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM) . 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2].

Product Specifications

CAS Number

[71186-53-3]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-hydroxydecanoate-sodium.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 12.5 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

CCCCCC(O)CCCC(O[Na])=O

Molecular Formula

C10H19NaO3

Molecular Weight

210.25

Precautions

H315, H319

References & Citations

[1]Congna Zi, et al. Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44 (6) :1353-1362.|[2]Xiantao Li, et al. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta. 2010 Mar;1800 (3) :385-91.|[3]M G Marina Prendes, et al. Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats. J Physiol Biochem. 2005 Sep;61 (3) :447-56.