NSI-189 (phosphate)
Product Specifications
UNSPSC Description
NSI-189 phosphate is the phosphate salt form of NSI-189 (HY-13999). NSI-189 phosphate stimulates the neurogenesis of neural stem cells. NSI-189 phosphate exhibits neuroprotective effect in Streptozotocin (HY-13753)-induced diabetic mouse model, improves neurological function and cognitive ability after stroke in rat middle cerebral artery occlusion (MCAo) model, and exhibits antidepressant efficacy[1].
Target Antigen
Akt; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nsi-189-phosphate.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC1)CC2=CC=CC=C2)C3=CC=CN=C3NCCC(C)C.O=P(O)(O)O
Molecular Weight
464.49
References & Citations
[1]McIntyre RS, et al., The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects. Expert Opin Investig Drugs. 2017 Jun;26(6):767-770.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13999A1/NSI-189-phosphate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13999A1/NSI-189-phosphate-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1270138-41-4
Available Sizes
Curated Selection
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