VU533
APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research[1].
Product Specifications
CAS Number
923417-09-8
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/vu533.html
Purity
99.71
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C(C)C=C1
Molecular Formula
C21H22FN3O3S2
Molecular Weight
447.55
References & Citations
[1]Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18 (8) :1891-1904.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLD
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ERLEC1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
![Rabbit IgG Fc Isotype Control [FITC]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
KDM1B Recombinant Antibody, AbBy Fluor™ 680 Conjugated
KDM1B Recombinant Antibody, AbBy Fluor™ 680 Conjugated
MCherry Polyclonal Antibody, AbBy Fluor™ 750 Conjugated