RSC133

RSC133 exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. RSC133 effectively facilitates reprogramming of human somatic cells to pluripotent stem cells and supports the maintenance of an undifferentiated state of human pluripotent stem cells[1].

Product Specifications

CAS Number

[1418131-46-0]

UNSPSC

12352005

Hazard Statement

H302, H411

Target

DNA Methyltransferase; HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/rsc133.html

Purity

98.45

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

NC(C1=CC=CC(NC(/C=C/C2=CNC3=CC=CC=C23)=O)=C1)=O

Molecular Formula

C18H15N3O2

Molecular Weight

305.33

Precautions

H302, H411

References & Citations

[1]Lee J, et al. A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angew Chem Int Ed Engl. 2012 Dec 7;51 (50) :12509-13.