Piperine (Standard)

Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3].

Product Specifications

CAS Number

[94-62-2]

Product Name Alternative

Bioperine (Standard) ; 1-Piperoylpiperidine (Standard)

UNSPSC

12352005

Hazard Statement

H302, H401, H411

Target

Autophagy; Endogenous Metabolite; P-glycoprotein; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/piperine-standard.html

Purity

98.55

Smiles

O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2

Molecular Formula

C17H19NO3

Molecular Weight

285.34

Precautions

H302, H401, H411

References & Citations

[1]Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3 (1) :9. Epub 2015 Oct 29.|[2]Meghwal M, et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27 (8) :1121-30.|[3]Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.|[4]Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.