Pyrene azide 3
Pyrene azide 3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Pyrene azide 3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
2252168-06-0
UNSPSC
12352005
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyrene-azide-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCN=[N+]=[N-])CCCC1=C(C2=C34)C=CC4=CC=CC3=CC=C2C=C1
Molecular Formula
C26H28N4O3
Molecular Weight
444.53
References & Citations
[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1014.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Frequently Asked Questions
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