Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Lenvatinib-d4

Lenvatinib-d4 is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

Product Specifications

CAS Number

[2264050-65-7]

Product Name Alternative

E7080-d4

UNSPSC

12352005

Target

C-Kit; FGFR; PDGFR; RET; VEGFR

Type

Isotope-Labeled Compounds

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Purity

99.59

Solubility

10 mM in DMSO|DMSO : ≥ 12.78mg/mL

Smiles

O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC4C([2H])(C4([2H])[2H])[2H])=O)C(Cl)=C3)C2=C1)N

Molecular Formula

C21H15D4ClN4O4

Molecular Weight

430.88

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kudo M, et al. Lenvatinib versus Bay 43-9006 in first-line treatment of patients with unresectable hepatocellularcarcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018 Mar 24;391 (10126) :1163-1173.|[3]Suyama K, et al. Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers. Cancer Control. 2018 Jan-Dec;25 (1) :1073274818789361.|[4]Matsui J, et al. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer. 2008, 122 (3), 664-671.|[5]Matsui J, et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res. 2008, 14 (17),545.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FPR1 Antibody
DF4881-01 100 µL

FPR1 Antibody

Ask
View Details
FPR1 Antibody
DF4881-02 200 µL

FPR1 Antibody

Ask
View Details
Chicken Valine ELISA Kit
MBS7278594-01 48 Well

Chicken Valine ELISA Kit

Ask
View Details
Chicken Valine ELISA Kit
MBS7278594-02 96 Well

Chicken Valine ELISA Kit

Ask
View Details
Chicken Valine ELISA Kit
MBS7278594-03 5x 96 Well

Chicken Valine ELISA Kit

Ask
View Details
Chicken Valine ELISA Kit
MBS7278594-04 10x 96 Well

Chicken Valine ELISA Kit

Ask
View Details