SEH inhibitor-7

SEH inhibitor-7 (compound c-2) is an inhibitor of soluble epoxide hydrolase (sEH) with IC50s of 0.15 μM (mouse sEH) and 6.2 μM (human sEH), respectively. soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation[1].

Product Specifications

CAS Number

[340221-20-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Epoxide Hydrolase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/seh-inhibitor-7.html

Purity

99.50

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C(OC)C=C1)CC2CCCCC2

Molecular Formula

C15H21NO2

Molecular Weight

247.33

Precautions

H302, H315, H319

References & Citations

[1]Kim IH, et al. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48 (10) :3621-9.