(E) -Guanabenz

(E) -Guanabenz ((E) -Wy-8678) is an orally active central α2-adrenoceptor agonist. (E) -Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E) -Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E) -Guanabenz can be used for researching hypertension and Parkinson disease[1][2].

Product Specifications

CAS Number

[60329-03-5]

Product Name Alternative

(E) -Wy-8678

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e-guanabenz.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

Molecular Formula

C8H8Cl2N4

Molecular Weight

231.08

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107.|[2]Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331.