NIC-12
NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages[1].
Product Specifications
CAS Number
2409826-23-7
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nic-12.html
Solubility
10 mM in DMSO
Smiles
CC(C1=NN(C(C2=CC3=C(N21)C=C(S3)Cl)=O)CC(N[C@@H]4CCCN(C4)CC5CC5)=O)C
Molecular Formula
C22H28ClN5O2S
Molecular Weight
462.01
References & Citations
[1]Vande Walle L, et al. Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency. Life Sci Alliance. 2024 Mar 22;7 (6) :e202402644.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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