Prostratin
Prostratin, a natural terpenoid compound, is a PKC activator, with a Ki of 12.5 nM and shows inhibitory effect on HIV-1.
Product Specifications
CAS Number
60857-08-1
UNSPSC
12352211
Target
HIV; PKC
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/prostratin.html
Purity
99.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Molecular Formula
C22H30O6
Molecular Weight
390.47
References & Citations
[1]Gustafson KR, et al. A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35 (11) :1978-86.|[2]Shen X, et al. The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 2015 Jan 28;356 (2 Pt B) :686-96.|[3]Wang H, et al. Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. Biomed Res Int. 2014;2014:968027.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKC
Available Sizes
Frequently Asked Questions
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