Lesogaberan (hydrochloride)
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptor. The affinity (Kis) of Lesogaberan hydrochloride for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan hydrochloride inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action[1].
Product Specifications
CAS Number
2925644-17-1
Product Name Alternative
AZD-3355 (hydrochloride)
UNSPSC
12352211
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lesogaberan-hydrochloride.html
Purity
98.0
Solubility
DMSO : 240 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=P(C[C@H](F)CN)O.[H]Cl
Molecular Formula
C3H10ClFNO2P
Molecular Weight
177.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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