Cephaeline (dihydrochloride)
Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC50 of 121 μM.
Product Specifications
CAS Number
[5853-29-2]
Product Name Alternative
(-) -Cephaeline (dihydrochloride) ; NSC 32944
UNSPSC
12352005
Hazard Statement
H301
Target
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/(-)-Cephaeline_(dihydrochloride).html
Purity
98.95
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)
Smiles
Cl[H].CC[C@@H](CN1CC2)[C@H](C[C@@]1([H])C3=C2C=C(OC)C(OC)=C3)C[C@]4([H])C5=CC(OC)=C(O)C=C5CCN4.Cl[H]
Molecular Formula
C28H40Cl2N2O4
Molecular Weight
539.53
Precautions
H301
References & Citations
[1]Asano T, et al. Metabolism of ipecac alkaloids Cephaeline and Emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24 (6) :678-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP2
Available Sizes
Curated Selection
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