TASK-1-IN-1
TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.
Product Specifications
CAS Number
600125-11-9
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/task-1-in-1.html
Concentration
10mM
Purity
98.36
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
CCC1=CC=CC=C1NC(C2=CC=CC(NC(C3=CC=CC=C3)=O)=C2)=O
Molecular Formula
C22H20N2O2
Molecular Weight
344.41
References & Citations
[1]Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65 (22) :15014-15027.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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