12 (R) -HETE

12 (R) -HETE is a metabolite of Arachidonic acid, AA (HY-109590) and can be found in skin from psoriatic lesions. 12 (R) -HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium[1][2][3][4].

Product Specifications

CAS Number

[82337-46-0]

UNSPSC

12352211

Target

Aryl Hydrocarbon Receptor; Na+/K+ ATPase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/12-r-hete.html

Concentration

312.04 μM * 100 μL in Ethanol

Purity

99.90

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(O)=O)O

Molecular Formula

C20H32O3

Molecular Weight

320.47

References & Citations

[1]Schwartzman ML, et al., 12 (R) -hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+, K+-ATPase in the cornea. Proc Natl Acad Sci U S A. 1987 Nov;84 (22) :8125-9. |[2]Bacon KB, et al., Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. Br J Pharmacol. 1988 Nov;95 (3) :966-74.|[3]Powell WS, et al., Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. J Leukoc Biol. 1995 Feb;57 (2) :257-63.|[4]Chiaro CR, et al., 12 (R) -Hydroxy-5 (Z),8 (Z),10 (E),14 (Z) -eicosatetraenoic acid [12 (R) -HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol. 2008 Dec;74 (6) :1649-56.