(-) -Syringaresinol

(-) -Syringaresinol is an orally active isomer of syringaresinol (HY-N8307) found in Annona Montana. (-) -Syringaresinol exhibits antioxidant, anti-inflammatory, and anticancer activities. (-) -Syringaresinol can alleviate ulcerative colitis via the PI3K-Akt/MAPK/Wnt signaling pathway. (-) -Syringaresinol inhibits HL-60 cell proliferation by arresting the G1 phase and inducing apoptosis. (-) -Syringaresinol inhibits LPS (HY-D1056) -induced microglial activation by downregulating the NF-κB p65 signaling pathway and its interaction with ERβ, exerting anti-neuroinflammatory effects[1][2][3].

Product Specifications

CAS Number

[6216-81-5]

UNSPSC

12352005

Target

Akt; Apoptosis; Bcl-2 Family; CD20; CDK; COX; Drug Isomer; GSK-3; IFNAR; Interleukin Related; NF-κB; NO Synthase; p38 MAPK; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-syringaresinol.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C([C@@H]2OC[C@]3([H])[C@@]2([H])CO[C@H]3C4=CC(OC)=C(O)C(OC)=C4)C=C1OC

Molecular Formula

C22H26O8

Molecular Weight

418.44

References & Citations

[1]Liu Y, et al. (-) -Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses. Phytomedicine. 2024 Feb;124:155292. |[2]Park BY, et al. (-) -Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis. Int Immunopharmacol. 2008 Jul;8 (7) :967-73. |[3]Zhang L, et al. (-) -Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ. Int Immunopharmacol. 2021 Oct;99:107986.