CXCR4 antagonist 10

CXCR4 antagonist 10 (compound 21) is a potent antagonist of CXCR4, with the IC50 of 7.8 nM. CXCR4 antagonist 10 plays an important role in cancer research[1].

Product Specifications

CAS Number

[3056005-98-9]

UNSPSC

12352209

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cxcr4-antagonist-10.html

Smiles

O=C(N[C@@H](C)C(N[C@@H](CN1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=C(C=CC=C3)C3=C2)C(N[C@@H](CC4=CNC=N4)C(N[C@H](C(O)=O)CCC1=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC(C)=O

Molecular Formula

C44H62N16O10

Molecular Weight

975.06

References & Citations

[1]Anna Maria Trotta, et al. Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification. Eur J Med Chem. 2024 Sep 25:279:116911.