Peresolimab

Peresolimab is a humanized IgG1-κ antibody targeting to PD-1. Peresolimab potentially stimulates physiological immune inhibitory pathways to restore immune homeostasis. Peresolimab can be used in research of rheumatoid arthritis[1][2].

Product Specifications

CAS Number

[2411580-63-5]

Product Name Alternative

LY-3462817

UNSPSC

12352203

Target

PD-1/PD-L1

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/peresolimab.html

Purity

99.62

Solubility

10 mM in DMSO|H2O

Smiles

[Peresolimab]

Molecular Weight

(145.16 kDa)

References & Citations

[1]Tuttle J, et al. Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis. Reply. N Engl J Med. 2023 Jul 27;389 (4) :378-379.|[2]Leane CM, et al., PD-1 regulation of pathogenic IL-17-secreting γδ T cells in experimental autoimmune encephalomyelitis. Eur J Immunol. 2024 Oct;54 (10) :e2451212.