IWP-12
IWP-12 is a potent inhibitor of porcupine (PORCN) and inhibits cell-autonomous Wnt signaling with an IC50 of 15 nM[1].
Product Specifications
CAS Number
[688353-45-9]
UNSPSC
12352005
Target
Acyltransferase; Wnt
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/iwp-12.html
Purity
99.53
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=C(N1C)SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)CC(C)S2
Molecular Formula
C18H18N4O2S3
Molecular Weight
418.56
References & Citations
[1]Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56 (6) :2700-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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