IWP-12

IWP-12 is a potent inhibitor of porcupine (PORCN) and inhibits cell-autonomous Wnt signaling with an IC50 of 15 nM[1].

Product Specifications

CAS Number

[688353-45-9]

UNSPSC

12352005

Target

Acyltransferase; Wnt

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/iwp-12.html

Purity

99.53

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=C(N1C)SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)CC(C)S2

Molecular Formula

C18H18N4O2S3

Molecular Weight

418.56

References & Citations

[1]Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56 (6) :2700-4.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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