8-Bromo-cAMP sodium salt
Product Specifications
Product Name Alternative
8-Br-Camp sodium salt
UNSPSC Description
8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells[1][2].
Target Antigen
Apoptosis; PKA
Type
Reference compound
Related Pathways
Apoptosis;Stem Cell/Wnt;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-Bromo-cAMP_sodium_salt.html
Purity
99.91
Solubility
DMSO : ≥ 125 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
BrC1=NC2=C(N=CN=C2N)N1[C@H](O[C@@](CO3)([H])[C@@]4([H])OP3(O[Na])=O)[C@@H]4O
Molecular Weight
430.08
References & Citations
[1]Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41.|[2]Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11(41):6538-42. |[3]Baek MO, et al. Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization. Exp Mol Med. 2018 Oct 30;50(10):1-11.|[4]Wang S, et al. Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. Onco Targets Ther. 2018 Jul 2;11:3765-3774Cell Mol Life Sci. 2022 Nov 13;79(12):589.|Cell Oncol. 2023 Mar 20.|Cell Signal. 2024 Sep 27:111438.|EMBO J. 2024 Sep 11.|Environ Health (Wash). 2024 Aug 16;2(11):776-785.|Hum Reprod. 2021 Jan 1;36(1):145-159.|Inflammation. 2022 Jul 7.|J Assist Reprod Genet. 2024 Mar 21.|J Bone Miner Metab. 2021 May 14.|J Hazard Mater. 2024 Jun 7:475:134854.|Korean J Pain. 2023 Jul 1;36(3):335-346.|Mol Cell Endocrinol. 2023 May 31;111952.|Part Fibre Toxicol. 2022 Feb 17;19(1):13.|Reprod Biol Endocrinol. 2022 Sep 22;20(1):142.|Reprod Sci. 2022 Oct 7.|Res Sq. 2024 Sep 09.|Research Square Preprint. 2021 Jul|Research Square Preprint. 2021 Jul.|Sci Total Environ. 2022 Oct 10;842:156854.|SSRN. 2023 Aug 1.|Theriogenology. 2022 Jun 19;189:118-126.|BMC Biol. 2024 May 3;22(1):104.|J Assist Reprod Genet. 2024 Sep 14.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12306/8-Bromo-cAMP-sodium-salt-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12306/8-Bromo-cAMP-sodium-salt-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
76939-46-3
Available Sizes
Curated Selection
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