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8-Bromo-cAMP sodium salt

8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA) . 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells[1][2].

Product Specifications

CAS Number

[76939-46-3]

Product Name Alternative

8-Br-Camp sodium salt

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; PKA

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-Bromo-cAMP_sodium_salt.html

Purity

99.91

Solubility

DMSO : ≥ 125 mg/mL|H2O : ≥ 100 mg/mL

Smiles

BrC1=NC2=C(N=CN=C2N)N1[C@H](O[C@@](CO3)([H])[C@@]4([H])OP3(O[Na])=O)[C@@H]4O

Molecular Formula

C10H10BrN5NaO6P

Molecular Weight

430.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7 (2) :331-41.|[2]Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11 (41) :6538-42. |[3]Baek MO, et al. Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization. Exp Mol Med. 2018 Oct 30;50 (10) :1-11.|[4]Wang S, et al. Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. Onco Targets Ther. 2018 Jul 2;11:3765-3774

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

BioRxiv. 2025 March 25.|Cell Mol Life Sci. 2022 Nov 13;79 (12) :589.|Cell Oncol (Dordr) . 2023 Aug;46 (4) :953-967.|Cell Signal. 2024 Dec:124:111438.|Commun Biol. 2025 Jul 4;8 (1) :995.|EMBO J. 2024 Nov;43 (21) :5018-5036.|Environ Health (Wash) . 2024 Aug 16;2 (11) :776-785.|Hum Reprod. 2021 Jan 1;36 (1) :145-159.|Inflammation. 2022 Dec;45 (6) :2419-2432.|J Assist Reprod Genet. 2024 Jun;41 (6) :1645-1659.|J Bone Miner Metab. 2021 Sep;39 (5) :769-779.|J Hazard Mater. 2024 Jun 7:475:134854.|J Proteomics. 2025 Apr 3:316:105437.|Korean J Pain. 2023 Jul 1;36 (3) :335-346.|Mol Cell Endocrinol. 2023 Aug 20:574:111952.|Part Fibre Toxicol. 2022 Feb 17;19 (1) :13.|Reprod Biol Endocrinol. 2022 Sep 22;20 (1) :142.|Reprod Sci. 2023 Apr;30 (4) :1281-1290.|Res Sq. 2024 Sep 09.|Research Square Preprint. 2021 Jul|Research Square Preprint. 2021 Jul.|Sci Total Environ. 2022 Oct 10:842:156854.|SSRN. 2023 Aug 1.|Theriogenology. 2022 Sep 1:189:118-126.|University of Bonn. 2025.|Andrology. 2025 Jun 16.|Biochem Biophys Res Commun. 2025 Nov 19:790:152919.|Biochem Pharmacol. 2025 Jun 23:117060.|BMC Biol. 2024 May 3;22 (1) :104.|Chem Res Toxicol. 2025 Jul 21;38 (7) :1266-1280.|J Assist Reprod Genet. 2024 Nov;41 (11) :3189-3200.|J Mol Histol. 2025 Oct 22;56 (6) :348.

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