Ambuic acid

Ambuic acid exhibits antimicrobial activity against Staphylococcus aureus, with IC50 of 43.9 μM for strain ATCC 6538. Ambuic acid is an inhbitor for the biosynthesis of cyclic peptide quorum sensing molecules (quormones) in gram-positive bacteria. Ambuic acid exhibits anti-inflammatory activity through ERK/JNK/MAPK signaling pathway[1][2][3].

Product Specifications

CAS Number

[340774-69-8]

Product Name Alternative

(+) -Ambuic acid

UNSPSC

12352005

Target

COX; ERK; JNK; NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ambuic-acid.html

Purity

98.00

Smiles

O=C(O)/C(C)=C/C[C@]12C(C(/C=C/CCCCC)=C(CO)[C@@H](O)[C@@]1([H])O2)=O

Molecular Formula

C19H26O6

Molecular Weight

350.41

References & Citations

[1]Zhang Q, et al., Anti-inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK/JNK mitogen-activated protein kinase signaling pathway. Exp Ther Med. 2018 Aug;16 (2) :1538-1546.|[2]Nakayama J, et al., Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria. Antimicrob Agents Chemother. 2009 Feb;53 (2) :580-6.|[3]Ding G, et al., Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp. J Nat Prod. 2009 Jan;72 (1) :182-6.