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SB-649915

SB-649915 is a potent 5-HT1A/1B autoreceptor antagonist, with the pKi values of 8.6, 8.0, respectively and 5-HT reuptake inhibitor in native tissue systems and palys an important role in antidepressant research[1].

Product Specifications

CAS Number

[420785-70-2]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-649915.html

Smiles

O=C1COC2=CC=C(CC3CCN(CCOC4=C5C=CC(C)=NC5=CC=C4)CC3)C=C2N1

Molecular Formula

C26H29N3O3

Molecular Weight

431.53

References & Citations

[1]Claire Scott, et al. SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue. Eur J Pharmacol. 2006 Apr 24;536 (1-2) :54-61.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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