Squalene

Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity[1][2].

Product Specifications

CAS Number

[111-02-4]

Product Name Alternative

Super Squalene; trans-Squalene; AddaVax

UNSPSC

12352211

Hazard Statement

H304

Target

Endogenous Metabolite; Fungal; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Squalene.html

Purity

98.0

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C

Molecular Formula

C30H50

Molecular Weight

410.72

Precautions

H304

References & Citations

[1]Muzalevskaya EN, et al. SQUALENE: PHYSIOLOGICAL AND PHARMACOLOGICAL PROPERTIES. Eksp Klin Farmakol. 2015;78 (6) :30-6.|[2]Fernando Warleta, et al. Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. Food Chem Toxicol. 2010 Apr;48 (4) :1092-100. |[3]Clara Gabás-Rivera, et al. Dietary squalene increases high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice. PLoS One. 2014 Aug 12;9 (8) :e104224.