PFB-FDGlu
PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis[1].
Product Specifications
CAS Number
[209540-62-5]
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pfb-fdglu.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
OC[C@H]1O[C@@H](OC2=CC3=C(C=C2)C4(C(C=C5)=C(C(O4)=O)C=C5NC(C6=C(C(F)=C(C(F)=C6F)F)F)=O)C7=C(C=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)O3)[C@H](O)[C@@H](O)[C@@H]1O
Molecular Formula
C39H32F5NO16
Molecular Weight
865.66
References & Citations
[1]Hughes LP, et al. Flow Cytometry Measurement of Glucocerebrosidase Activity in Human Monocytes. Bio Protoc. 2020;10 (7) :e3572.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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