SCFSkp2-IN-2

SCFSkp2-IN-2 (Compound AAA-237) is a Skp2 inhibitor with a KD of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities[1].

Product Specifications

CAS Number

[1375060-02-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/scfskp2-in-2.html

Purity

99.01

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCN(C1=CC(O)=C(C=C1)/C=N/NC(C2=CN=CC=C2)=O)CC

Molecular Formula

C17H20N4O2

Molecular Weight

312.37

Precautions

H302, H315, H319

References & Citations

[1]Liu J, et al. Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence. Pharmacol Res. 2022 Jul;181:106259.