CRBN-6-5-5-VHL
CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3. (Pink: VHL ligand (HY-125845) ; Blue: E3 Ligase ligand (HY-10984) ; Black: linker (HY-403544) ) [1].
Product Specifications
CAS Number
[2362575-45-7]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
E1/E2/E3 Enzyme; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crbn-6-5-5-vhl.html
Purity
99.45
Solubility
DMSO : 113.33 mg/mL (ultrasonic)
Smiles
O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCOCCCCCOCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]4O)[C@@H](C4)C(NCC5=CC=C(C(SC=N6)=C6C)C=C5)=O)=O)=O
Molecular Formula
C51H69N7O10S
Molecular Weight
972.20
Precautions
H315, H319, H320
References & Citations
[1]Christian Steinebach, et al. PROTAC-mediated crosstalk between E3 ligases. Chem Commun (Camb) . 2019 Feb 5;55 (12) :1821-1824.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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