Verapamil (hydrochloride) (Standard)

Verapamil (hydrochloride) (Standard) is the analytical standard of Verapamil (hydrochloride) . This product is intended for research and analytical applications. Verapamil hydrochloride ((±) -Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

Product Specifications

CAS Number

[152-11-4]

Product Name Alternative

(±) -Verapamil (hydrochloride) (Standard) ; CP-16533-1 (hydrochloride) (Standard)

UNSPSC

12352005

Hazard Statement

H301

Target

Calcium Channel; Cytochrome P450; P-glycoprotein; Reference Standards

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/verapamil-hydrochloride-standard.html

Purity

99.81

Solubility

DMSO : ≥ 31 mg/mL

Smiles

[H]Cl.COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C=C1OC

Molecular Formula

C27H39ClN2O4

Molecular Weight

491.06

Precautions

H301

References & Citations

[1]Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25 (3) :743-746.|[2]Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.|[3]Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8 (8) :e71567.|[4]Rehnqvist N, et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS) . Eur Heart J. 1996 Jan;17 (1) :76-81.|[5]Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35 (5) :93.