3’-beta-C-Ethynyl inosine
3’-beta-C-Ethynyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-beta-C-Ethynyl inosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-beta-c-ethynyl-inosine.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N([C@H]3[C@H](O)[C@](O)(C#C)[C@@H](CO)O3)C=N2)N=CN1
Molecular Formula
C12H12N4O5
Molecular Weight
292.25
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
RUVBL1 (RuvB-like 1, RVB1, TIH1, ECP54, TIP49, INO80H, NMP238, PONTIN, TIP49A, Pontin52) (AP)
RUVBL1 (RuvB-like 1, RVB1, TIH1, ECP54, TIP49, INO80H, NMP238, PONTIN, TIP49A, Pontin52) (AP)
MARCO (Macrophage Receptor MARCO, Macrophage Receptor with Collagenous Structure) (MaxLight 490) discontinued
LITAF (LPS-induced TNF-alpha Factor, Lipopolysaccharide-induced Tumor Necrosis Factor-alpha Factor, PIG7, SIMPLE, TP53I7) (FITC)