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Serotonin (hydrochloride)

Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

Product Specifications

CAS Number

153-98-0

Product Name Alternative

5-Hydroxytryptamine (hydrochloride) ; 5-HT (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301, H361

Target

5-HT Receptor; COMT; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Serotonin_hydrochloride.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(NC=C2CCN)C=C1.[H]Cl

Molecular Formula

C10H13ClN2O

Molecular Weight

212.68

Precautions

H301, H361

References & Citations

[1]Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite; Microbial Metabolite; MUC4

Citation 01

Authorea. September 19, 2022.|Behav Brain Res. 2025 May 7:115620.|Biochem Biophys Res Commun. 2025 Sep 19:785:152676.|bioRxiv. 2023 Oct 13.|bioRxiv. 2024 November 03.|bioRxiv. 2025 Sep 28.|Food Res Int. 2025 Aug:214:116675.|Immunity. 2025 Aug 12:S1074-7613 (25) 00314-0.|J Dent Sci. 2025 Apr 15.|J Immunother Cancer. 2021 Jul;9 (7) :e002383.|Nature. 2025 Jul;643 (8070) :192-200.|Res Sq. 2024 Jun 11.|Research Square Preprint. 2023 Dec 28.|SSRN. 2025 Apr 24.|bioRxiv. 2024 November 03.|bioRxiv. 2025 Oct 14.|Cell Stem Cell. 2025 May 1;32 (5) :778-794.e10.|Curr Res Food Sci. 2024 Apr 26:8:100754.|Int J Mol Sci. 2022 Oct 17;23 (20) :12420.|iScience. 2025 Jun 18;28 (7) :112931.|iScience. 2025 Nov 18.|J Exp Clin Cancer Res. 2024 Oct 10;43 (1) :284.|Neurosci Bull. 2025 Jul;41 (7) :1229-1245.

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