AZ20
AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM) .
Product Specifications
CAS Number
1233339-22-4
UNSPSC
12352005
Hazard Statement
H302
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ20.html
Purity
99.40
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O
Molecular Formula
C21H24N4O3S
Molecular Weight
412.51
Precautions
H302
References & Citations
[1]Foote KM, et al. Discovery of 4-{4-[ (3R) -3-Methylmorpholin-4-yl]-6-[1- (methylsulfonyl) cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20) : a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATR
Available Sizes
Frequently Asked Questions
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