AZ20

AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM) .

Product Specifications

CAS Number

[1233339-22-4]

UNSPSC

12352005

Hazard Statement

H302

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZ20.html

Purity

99.40

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O

Molecular Formula

C21H24N4O3S

Molecular Weight

412.51

Precautions

H302

References & Citations

[1]Foote KM, et al. Discovery of 4-{4-[ (3R) -3-Methylmorpholin-4-yl]-6-[1- (methylsulfonyl) cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20) : a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14