CGP35348

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].

Product Specifications

CAS Number

[123690-79-9]

UNSPSC

12352211

Hazard Statement

H302, H318, H410

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgp35348.html

Purity

98.0

Solubility

H2O : 83.33 mg/mL (ultrasonic)

Smiles

O=P(C(OCC)OCC)(CCCN)O

Molecular Formula

C8H20NO4P

Molecular Weight

225.22

Precautions

H302, H318, H410

References & Citations

[1]H R Olpe, et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors|[2]Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. |[3]A Puigcerver, et al. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40 (3) :157-62.